female gender and helicobacter pylori infection, the most important predisposition factors in a cohort of gastric cancer: a longitudinal study

Authors

shahram agah colorectal research center; iran university of medical sciences, tehran

hossein khedmat baqiyatallah research center for gastroenterology and liver disease; baqiyatallah university of medical sciences, tehran, iran

mohammad ebrahim ghamar-chehred baqiyatallah research center for gastroenterology and liver disease; baqiyatallah university of medical sciences, tehran, iran

reza hadi baqiyatallah research center for gastroenterology and liver disease; baqiyatallah university of medical sciences, tehran, iran

abstract

background: gastric cancer (gc) is one of the most common cancers in the world and helicobacter pylori (hp) infection is considered a causative factor. the aim of this study was to determine the characteristics and the associated factors of (gc) in a small cohort. methods: overall, 54 patients with diagnosed gastric cancer were followed-up at the department of gastroenterology & hepatology at baqiyatallah university of medical sciences. 37 (68.5%) of them were positive for h pylori infection in histopathological evaluations. univariate and multivariate regression analyses were used to determine the associations of demographic features and hp infection status with gc characteristics and prognosis. results: univariate analysis showed female gender (odds ratio (or): 6.53; 95% confidence interval (95%ci): 1.59-26.8; p=0.008), and illiteracy (compared to intermediate education; or: 5.9, 95%ci: 1.37-25.43; p=0.05) were associated significantly with higher rate of hp infection. after a mean±sd follow-up duration of 254±329 months, only female gender was significantly associated with hp infection in gc (or:4.56; 95% ci: 1.0-21.76; p=0.05). h pylori positive patients had significantly higher grade of gc (or: 3.97; 95% ci: 1.0-16.16; p=0.05), and a trend toward greater gc stage (or: 4.46, 95% ci: 9.39-21.23; p=0.06). there was no association between survival rate and h pylori infection. conclusion: in the current study, we found a significant association of female gender with gn and an association of higher grade of gc with female gender. these findings may indicate a sex disparity in susceptibility to hp infection regarding gc future studies of larger populations are recommended.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Female gender and Helicobacter pylori infection, the most important predisposition factors in a cohort of gastric cancer: A longitudinal study

Background: Gastric cancer (GC) is one of the most common Cancers in the world and Helicobacter pylori (HP) infection is considered a causative factor. The aim of this study was to determine the characteristics and the associated factors of (GC) in a small cohort. Methods: Overall, 54 patients with diagnosed gastric cancer were followed-up at the Department of Gastroenterology & Hepatology a...

full text

Female gender and Helicobacter pylori infection, the most important predisposition factors in a cohort of gastric cancer: A longitudinal study

BACKGROUND Gastric cancer (GC) is one of the most common Cancers in the world and Helicobacter pylori (HP) infection is considered a causative factor. The aim of this study was to determine the characteristics and the associated factors of (GC) in a small cohort. METHODS Overall, 54 patients with diagnosed gastric cancer were followed-up at the Department of Gastroenterology & Hepatology at B...

full text

The Role of Helicobacter Pylori Virulence Factors in Gastric Cancer

Introduction: Gastrointestinal (GI) cancers are considered among the most important causes of mortality and morbidity. Helicobacter pylori infection has been proven to be highly associated with the development of a variety of gastric diseases such as chronic gastritis, peptic ulcer disease (PUD), mucosa-associated lymphoid tissue (MALT), and gastric cancer (GC). To date, the exact role of the v...

full text

a comparative study of the relationship between self-, peer-, and teacher-assessments in productive skills

تمایل به ارزیابی جایگزین و تعویض آن با آزمون سنتی مداد و کاغذ در سالهای اخیر افزایش یافته است. اکثر زبان آموزان در کلاس های زبان از نمره نهایی که استاد تعیین میکند ناراضی اند. این تحقیق جهت بررسی ارزیابی در کلاس های زبان انگلیسی به هدف رضایتمندی زبان آموزان از نمره هایشان انجام گرفته است که در آن نمرات ارائه شده توسط سه گروه ارزیاب (ارزیابی خود دانشجو، همسالان واستاد) در مهارت های تولید (تکل...

15 صفحه اول

the most important demotivating factors among efl teachers in private english language institutes in mashhad

just as motivation is important in sla research, demotivation constitutes an important factor, too. there are many studies done on demotivation and burnout of teachers. many of these studies have been conducted on one or two aspects of english instruction. consequently, there are few studies which have been done on more than two aspects of english teaching. the aim of this study is to find out ...

Presence of cagA Gene in Patients with Gastric Cancer and Gastritis with Helicobacter pylori Infection

Background and purpose: Helicobacter pylori is a gram-negative, micro-aerophilic, and spiral-shaped bacillus. Infection with this bacterium can lead to gastritis, ulcers, and even gastric cancer. This study was conducted to evaluate the presence of the cagA gene among patients with gastritis and gastric cancer. Materials and methods: This study was performed in patients with gastritis (n=40) a...

full text

My Resources

Save resource for easier access later


Journal title:
caspian journal of internal medicine

جلد ۷، شماره ۲، صفحات ۱۳۶-۱۴۱

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023